Fresh analysis suggests that individuals who come off new weight-loss injections like Mounjaro or Wegovy can put back on shed pounds at a significantly accelerated pace than those who halt conventional diet and exercise regimens.
Findings released in a prominent medical journal demonstrates that while obese people often shed about a fifth of their total mass while on the medication, the mass comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"People buying these drugs must be informed of the risk of fast rebound weight gain when the medication ends," cautioned lead investigator Dr. Susan Jebb.
Such speed of recovery suggests a return to pre-treatment mass within about 18 months.
Comparing Therapies
The study, which reviewed dozens of studies involving over 9,000 of patients, compared the outcomes of GLP-1 agonists with other pills.
Scientists note that individuals who shed pounds through dieting usually experience a less rapid weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Experts believe the way of the injections accounts for the heightened rebound.
The injections copy a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production could lead to the body to produce less of its own natural GLP-1, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition researcher.
"Stopping of this hormone supplement results in hunger is unsuppressed, making overeating a significant risk."
A Chronic Condition?
Health authorities recommend the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts contend that, considering the likelihood of relapse, the therapy might need to be long-term.
This opinion is echoed by drug manufacturers, who note that the findings "emphasize the long-term nature of excess weight," akin to managing diseases like hypertension.
User Experiences
People who have come off the medication explain a intense resurgence of appetite.
"I experienced something flipping and you're instantly extremely hungry," recalled an individual.
The struggle is compounded if individuals have not established permanent lifestyle or habit modifications during therapy.
Significant Use
Recent estimates suggest that a significant number of adults in the UK have tried these injections in the last 12 months, with demand being substantial.
- Adoption is more common among females than men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
Finally, experts stress that while GLP-1 drugs are effective tools for shedding pounds, they are not a magic solution and lasting health benefits hinges on combined behavioural changes.
